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原纸Urol Int DOI:10.1159 / 000510248

收到:2020年5月4日接受:2020年7月17日在线发布:2020年9月30日

马蹄肾经皮肾镜取石术失败的相关因素调查及三种结石评分系统预测结果的比较Sinan Avci Volkan Caglayan Metin Kilic Sedat Oner

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Department of Urology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Y?ld?r?m/Bursa, Turkey

Abstract Introduction: We aimed to identify factors affecting percutaneous nephrolithotomy (PNL) outcomes among patients with horseshoe kidney (HSK) and assess the predictive accuracy of the Clinical Research Office of the Endourological Society (CROES), Guy’s Stone Score (GSS), and S.T.O.N.E. scoring systems. Methods: Data from 98 patients with HSK who underwent PNL between November 2010 and January 2020 were evaluated. Patients were divided into the stone-free (SF) and non-SF groups and compared according to demographic data, stone and surgical characteristics, and stone scoring systems. Multivariate logistic regression analysis was performed to identify factors associated with SF status. Results: Among the included patients, 87 were male and 11 were female (mean age: 47.37 ± 14.42 years). The SF rate was 84.7% (83 patients). Group analysis identified GSS (p < 0.001), CROES score (p < 0.001), S.T.O.N.E. score (p = 0.014), stone burden (p = 0.045), and multiplicity (p < 0.001) as factors associated with SF status. Among our cohort, 10 patients developed complications. All scoring systems were significantly correlated with SF status (CROES: r = ?0.442, p < 0.001; GSS:

[email protected] www.karger.com/uin

? 2020 S. Karger AG, Basel

r = 0.442, p < 0.001; S.T.O.N.E.: r = 0.250, p = 0.013), while CROES score was identified as an independent factor associated with SF status (95% CI: 0.937–0.987; p = 0.003). Conclusions: PNL is an effective method for treating nephrolithiasis among patients with HSK. Moreover, stone-related factors, such as larger size, multiplicity, and complexity, were associated with procedural failure. Finally, the CROES nomogram was a better predictor of SF status compared with other scoring systems. ? 2020 S. Karger AG, Basel

介绍

Horseshoe kidney (HSK), first described by Carpi in 1522, is the most common renal fusion abnormality, with a reported incidence of 1 in 400–666 individuals among the general population [1]. HSK is caused by the abnormal fusion of the metanephric blastema during the embryonic period [2]. The high ureter insertion limits the drainage ability of the renal collecting system. As such, individuals with HSK are more prone to urinary stasis, ureteropelvic obstruction, infection, and urolithiasis [3]. Studies have reported that nephrolithiasis is the most common complication of HSK, with incidence rates ranging from 21 to 60% [2]. Considering the anatomical feaVolkan Caglayan Department of Urology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Mimarsinan Mahallesi, No. Emniyet Cd. No. 35 Y?ld?r?m/Bursa 16310 (Turkey) volkantuysuz @ hotmail.com

下载者:乌得勒支大学图书馆131.211.12.11-2020/10/21 10:43:56

Keywords Percutaneous nephrolithotomy · Horseshoe kidney · Stone-free status

2

Urol Int DOI:10.1159 / 000510248

dural outcomes. Considering our clinical experience in the field, the present study aimed to identify factors affecting PNL outcomes among patients with HSKs and assess the predictive value of the 3 aforementioned stone scoring systems. Methods After institutional review board approval, data from 98 patients with HSK who underwent PNL between November 2010 and January 2020 were evaluated. The procedure was performed on patients with stones larger than 2 cm, those with SWL-resistant stones, and those who opted for PNL after receiving information regarding treatment alternatives. Preoperative Evaluation Detailed physical examinations, history taking, blood count, blood biochemistry assays, urine analysis, and urine culture were performed. All patients underwent kidney-ureter-bladder radiography, ultrasonography, and computed tomography (CT). Stone size was calculated using CT images. Stone burden was determined by multiplying the 2 largest diameters. All calculations (stone size, GSS, S.T.O.N.E. score, and CROES score) were performed by the same surgeon, while all stone scoring systems were divided into 3 groups for detailed investigation (220 for CROES; 5–6, 7–8, and ≥9 for S.T.O.N.E.; and 2, 3, and 4 for GSS). Demographic characteristics (i.e., age, gender, stone number, and surgical history) and perioperative parameters (i.e., presence of upper calyx access, access number, operative time, anesthesia time, type of anesthesia, complications, and length of hospitalization) were noted. Surgical Procedure All procedures, which were performed in the prone position, started with cystoscopy for ureteral catheter insertion. A contrast agent was then injected through the catheter to visualize the renal collecting system. Access was performed under fluoroscopic guidance, after which a guidewire was inserted into the collecting system. Serial dilators were used for tract dilation, and a 30F Amplatz sheath was positioned. Stone fragmentation was performed using a pneumatic lithotripter. The fragments were then extracted using a grasper. Smaller fragments were extracted through irrigation. After the procedure, antegrade pyelography was performed to check for stone clearance and a nephrostomy tube was inserted under fluoroscopic guidance. Stone clearance was assessed through CT 3-4 weeks after the procedure. The procedure was categorized as SF when no stone fragments were observed upon imaging. Patients were then divided into 2 groups according to the presence (non-SF group) and absence (SF group) of residual fragments. PNL-associated complications were recorded and classified according to the Clavien-Dindo classification [18]. Statistical Analysis Comparisons between groups were performed using Pearson’s χ2 test for categorical variables and the Mann-Whitney U test for continuous variables. Logistic regression analysis was performed to identify factors independently associated with outcomes. Rela-

Avci / Caglayan / Kilic / Oner

下载者:乌得勒支大学图书馆131.211.12.11-2020/10/21 10:43:56

tures of HSK, the treatment of nephrolithiasis has been a cause for concern among urologists. Currently, minimally invasive techniques, such as shock wave lithotripsy (SWL) and retrograde intrarenal surgery (RIRS), have been widely performed for the treatment of nephrolithiasis among individuals with HSKs [4]. Among such alternatives, SWL has been found to be well tolerated with reported stone-free rates (SFRs) ranging from 31 to 72% [5, 6]. Though minimally invasive, most of the patients require repeat SWL sessions to achieve higher SFRs, which have been shown to decrease significantly with larger stones [7]. Meanwhile, studies have shown that utilizing RIRS for the treatment of nephrolithiasis among patients with HSK produced SFRs ranging from 70 to 88.2% [8, 9]. Despite the seemingly sufficient efficacy of RIRS for nephrolithiasis in HSK, stones should theoretically be split into smaller fragments and extracted. Otherwise, the probability for ancillary procedures may increase. Considering the benefits of adequate pelvicalyceal system drainage for the success of SWL and RIRS, percutaneous nephrolithotomy (PNL), which can be performed relatively independent of anatomic features, may be advantageous. The current European Association of Urology guidelines recommend PNL as an alternative treatment for stones ranging from 1 to 2 cm and as the first-line therapy for larger stones, regardless renal anatomical features [10]. Accordingly, previous studies had revealed that PNL was an effective modality for patients with HSK, with success rates ranging from 65.8 to 86.5% [11–17]. Although various studies have evaluated the efficacy of PNL among patients with HSK, the number of studies systemically investigating factors affecting outcomes of PNL and the predictive value of stone scoring systems have been, to the best of our knowledge, lacking. The success of PNL is primarily dependent on the patient (surgical history, body mass index, comorbidities, and anatomical abnormalities), stone (size, density, and location), and surgery-related factors (access number, access site, tract length, operative time, and surgeon’s experience) [18–20]. Recently, different stone scoring systems consisting of various combinations have been developed to assist surgeons in predicting the surgical outcomes of PNL [21–23]. Accordingly, Guy’s Stone Score (GSS), S.T.O.N.E. score, and the Clinical Research Office of the Endourological Society (CROES) nomogram have been the most widely used scoring systems. While GSS accounts for anatomical abnormalities as factors increasing PNL complexity, the CROES and S.T.O.N.E. scoring systems do not consider the same as factors affecting proce-

表1.单变量分析中的总队列和因素与残余结石发生率的关系

Total cohort (n = 98) Mean age, years Gender Male Female Preoperative hemoglobin, g/dL Preoperative creatinine, mg/dL Stone burden, mm2 CROES GSS S.T.O.N.E. Hounsfield unit Previous surgery + ? Stone, n Single Multiple Access, n Single Multiple Upper calyx access + ? Anesthesia type General Regional Complication + ? Hb drop Operation time, min Hospitalization, days

Patients with no residual stone (n = 83)

小孩起名网免费取名 Patients with residual stone (n = 15)

p值

46.87±14.56

47.37±14.42

44.07±15.55

0.471

87/88.8 11/11.2 14.54±1.59 0.98±0.26 509.2±477.8 237.02±56.87 2.63±0.56 7.55±1.34 893±294.2

73/87.95 10/12.05 14.53±1.62 0.98±0.26 452.07±402.55 247.74±53.40 2.52±0.50 7.39±1.27 884.6±290.9

14/93.3 1/6.7 14.63±1.52 0.99±0.29 825.47±711.58 177.73±35.59 3.27±0.46 8.47±1.41 905.4±303.6

0.543 0.937 0.901 0.043

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原纸Urol Int DOI:10.1159 / 000510248 收到:2020年5月4日接受:2020年7月17日在线发布:2020年9月30日 F ...的调查
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